Diterpenoid Alkaloids and Phenol Glycosides from Aconitum Naviculare (Brühl) Stapf

Author:

Dall'Acqua Stefano1,Shrestha Bharat B.2,Gewali Mohan Bikram3,Jha Pramod Kumar2,Carrara Maria4,Innocenti Gabbriella1

Affiliation:

1. Department of Pharmaceutical Sciences, University of Padova, Padova, Italy

2. Central Department of Botany, Tribhuvan University, Kirtipur, Kathmandu, Nepal

3. Central Department of Chemistry, Tribhuvan University, Kirtipur, Kathmandu, Nepal

4. Department of Pharmacology and Anesthesiology, University of Padova, Padova, Italy

Abstract

Phytochemical investigation of the aerial parts of Aconitum naviculare, a medicinal plant used in traditional Nepalese medicine, led to the isolation and characterization of two new diterpenoid alkaloids, navirine B (1), and navirine C (2), along with (+) chellespontine (3), kaempferol-7-O-β-D-glucopyranosyl(1→3)α-L-rhamnopyranoside (4), kaempferol-7-O α-L-rhamnopyranoside,3-O-β-D-glucopyranoside (5), p-coumaric-4-O-β-D-glucopyranoside acid (6), and ferulic-4-O-β-D-glucopyranoside acid (7). The structures of the isolated compounds were elucidated on the basis of extensive analyses of 1D and 2D NMR spectra (HMQC, HMBC, COSY, ROESY) and HR-MS data. The antiproliferative activity of alkaloids 1–3 against human tumor cell lines (LoVo and 2008) was also evaluated.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Reference13 articles.

1. AmiyaT, BandoH. (1988) Aconitum alkaloid, in The Alkaloids: Chemistry and Biology, BrossiA. (Ed) Academic Press Inc, San Diego, CA, Vol. 34, Chapter 3, 95–177.

2. The effects of Aconitum alkaloids on the central nervous system

3. Inhibitory Effects of Diterpenoid Alkaloids on the Growth of A172 Human Malignant Cells

4. A new diterpenoid alkaloid from a Tibetan medicinal herb Aconitum naviculare Stapf

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