Biotransformation of (-)-(10E,15S)-10,11-Dehydrocurvularin-Reference-Cited by-同舟云学术

Biotransformation of (-)-(10E,15S)-10,11-Dehydrocurvularin

Published:2015-07 Issue:7 Volume:10 Page:1934578X1501000
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Deng Zhangshuang¹²,Deng Aiping¹,Luo Dan¹,Gong Dachun²,Zou Kun¹,Peng Yan³,Guo Zhiyong¹

Affiliation:

1. Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang, 443002, China

2. Yichang Key Laboratory of Biocatalysis, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang, 443002, China

3. The First College of Clinical Medical Science, China Three Gorges University, Yichang, 443002, China

Abstract

(-)-(10 E,15 S)-10,11-Dehydrocurvularin (1), produced from an associated-fungus of Scolopendra subspinipes mutilans on a gram scale, was microbiologically converted to curvularin (2) and 5-methoxycurvularin (3) by Antrodiella semisupina in 61% totally isolated yield. The structures of these compounds were elucidated on the basis of spectroscopic and mass spectrometric analysis. The undescribed assignments of 1H and 13C NMR spectral data for 5-methoxycurvularin (2) has now been explicitly provided. The cytotoxic activities of compounds 1-3 against four human cancer cell lines were evaluated. Dehydrocurvularin (1) showed moderate cytotoxicity against Caski and Hep-G2, and curvularin (2) was selectively cytotoxic against MDA-MB-231.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1501000735

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