Induction of Neuronal Differentiation in Neurosphere Stem Cells by Ellagic Acid Derivatives-Reference-Cited by-同舟云学术

Induction of Neuronal Differentiation in Neurosphere Stem Cells by Ellagic Acid Derivatives

Published:2009-04 Issue:4 Volume:4 Page:1934578X0900400
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Tabopda Turibio Kuiate¹,Ngoupayo Joseph¹,Liu Jia Wei²,Mitaine-Offer Anne-Claire³,Ngadjui Bonaventure Tchaleu¹,Lacaille-Dubois Marie-Aleth³,Luu Bang²

Affiliation:

1. Département de Chimie Organique, Université de Yaoundé I, BP 812 Yaoundé, Cameroun

2. Laboratoire de Chimie Organique des Substances Naturelles, LC3-UMR 7177 CNRS-Université Louis Pasteur, Centre de Neurochimie, 5 Rue Blaise Pascal 67084 Strasbourg, France

3. Université de Bourgogne, Faculté de Pharmacie, Laboratoire de Pharmacognosie, UMIB UPRES EA 3660, 7, Bd Jeanne d'Arc – B.P. 87900, 21079 Dijon cedex, France

Abstract

A bioassay-guided fractionation of methanol extracts of stem barks, combined with screening based on Epidermal Growth Factor (EGF)-responsive neural stem cells (erNSCs) differentiation assay, has been used. This study resulted in the isolation of 3,3′-di- O-methylellagic acid 1, 3,3′-di- O-methyl ellagic acid-4- O-β-D-xylopyranoside 2, ellagic acid 3, and arjunolic acid 4. Among them, compounds 1 and 2 exhibit potent induction of neuronal differentiation in neurosphere stem cells with no cytotoxic effect. These results indicate that compounds 1 and 2 may be useful as pharmacological agents for the treatment of neurodegenerative diseases. These compounds may account, for the use of T. superba in folk medicine for nervous system and mental disorders.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X0900400415

Reference11 articles.

1. Anti-diabetic activity of methanol/methylene chloride stem bark extracts of Terminalia superba and Canarium schweinfurthii on streptozotocin-induced diabetic rats

2. α-Glucosidase inhibitory constituents from stem bark of Terminalia superba (Combretaceae)

3. .ALPHA.-Glucosidase Inhibitors Ellagic Acid Derivatives with Immunoinhibitory Properties from Terminalia superba

4. Ellagic acid, pomegranate and prostate cancer — a mini review

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Secondary Metabolites from Polar Fractions of Piper umbellatum;Natural Product Communications;2012-05

2. Interactions between neural stem cells and biomaterials combined with biomolecules;Frontiers of Materials Science in China;2010-11-12