Chemical and Bioactivity Evaluation of the Bark of Neonauclea purpurea-Reference-Cited by-同舟云学术

Chemical and Bioactivity Evaluation of the Bark of Neonauclea purpurea

Published:2012-02 Issue:2 Volume:7 Page:1934578X1200700
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Karaket Netiya¹,Supaibulwatana Kanyaratt¹,Ounsuk Supatsara¹,Bultel-Poncé Valérie²³,Pham Van Cuong⁴,Bodo Bernard²

Affiliation:

1. Department of Biotechnology, Faculty of Science, Mahidol University, Bangkok, 10400, Thailand

2. USM 5298 CNRS/MNHN, MCAM-CP54, Muséum National d'Histoire Naturelle, 63 rue Buffon, 75231 Paris Cedex 05, France

3. Institut des Biomolécules Max Mousseron IBMM-IMR 5247 Université Montpellier1/Université Monpellier 2/CNRS-Faculté de Pharmacie, 15 Avenue Charles Flahault 34093 Montpellier Cedex 05, France

4. Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 hoang Ouoc Viet Road, Cau Giay, Hanoi, Viet Nam

Abstract

Bioassay-guided fractionation of the MeOH extract from the stem bark of Neonauclea purpurea used in traditional medicine, resulted in the isolation of 2 indole alkaloids, cadambine (1) and α-dihydrocadambine (2), as well as a quinolic compound, 2,6-dimethoxy-1,4-benzoquinone (3). Antimalarial activity evaluation showed that compounds 2 and 3 exhibited mild in vitro antimalarial activity against Plasmodium falciparum, the chloroquine-resistant strain K1 with IC50 values of 6.6 and 11.3 μM, respectively. Compounds 1 and 2 showed no cytotoxicity to monkey (Vero) cells, but compound 3 showed weak cytotoxicity with an IC50 value of 1.19 μM.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1200700208

Reference14 articles.

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2. Hypotensive Principles of Uncaria Hooks

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4. Plant Anticancer Agents. XI. 2,6-Dimethoxybenzoquinone as a Cytotoxic Constituent of Tibouchina pulchra

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