A Pregnane Derivative and an Anti-plasmodial Labdane Diterpenoid from the Stem Bark of Turraenthus Africanus-Reference-Cited by-同舟云学术

A Pregnane Derivative and an Anti-plasmodial Labdane Diterpenoid from the Stem Bark of Turraenthus Africanus

Published:2006-06 Issue:6 Volume:1 Page:1934578X0600100
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Akam Thomas M.¹,Tane Pierre²,Wabo Hippolyte K.²,Yong Joseph N.¹,Fanso-Free Samual N. Y.¹,Connolly Joseph D.³,Evans Cameron³,Farrugia Louis J.³

Affiliation:

1. Department of Chemistry, University of Buea, P.O. Box 63, Buea, Cameroon

2. Department of Chemistry, University of Dschang, P.O. Box 67, Dschang, Cameroon

3. Chemistry Department, University of Glasgow, G12 8QQ, Scotland, UK

Abstract

Chemical investigation of the stem bark of Turraeanthus africanus (Meliaceae) afforded a new pregnane derivative, 17α,20S-dihydroxypregn-4-ene-3,16-dione, named turraeasterodione, together with three known diterpenoids, methyl 14,15-epoxylabda-8(17),12E-dien-16-oate, 16-oxolabda-8(17),12E-dien-15-oic acid, and 16-acetoxy-12R,15-epoxylabda-8(17),13(16)-dien-15β-ol. Their structures were elucidated by spectroscopic and spectrometric methods. Methyl 14,15-epoxylabda-8(17),12E-dien-16-oate was found to exhibit anti-plasmodial activity against a chloroquine-resistant strain of Plasmodium falciparum.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X0600100603

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