Transdermal Delivery of Small-Sized Resveratrol Nanoparticles to Epidermis Using Anionic Phospholipids-Reference-Cited by-同舟云学术

Transdermal Delivery of Small-Sized Resveratrol Nanoparticles to Epidermis Using Anionic Phospholipids

Published:2020-09 Issue:9 Volume:15 Page:1934578X2095144
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Uchida Noriyuki¹^ORCID,Yanagi Masayoshi²,shimoda Kei³,Hamada Hiroki²^ORCID

Affiliation:

1. RIKEN Center for Emergent Matter Science, Wako, Saitama, Japan

2. Department of Life Science, Faculty of Science, Okayama University of Science, Kita-ku, Okayama, Japan

3. Department of Biomedical Chemistry, Faculty of Medicine, Oita University, Oita, Japan

Abstract

Composite nanoparticles composed of anionic phospholipid of 1,2-dipalmitoyl- sn-glycero-3-phosphorylglycerol (DPPG) and resveratrol (Res) were successfully prepared by mixing them in water and a subsequent heating/cooling process. Small-sized DPPG-Res nanoparticles (<60 nm) could be prepared by ultrasonic fragmentation. Upon addition of size-controlled fluorescently labeled Res (FLRes) nanoparticles stabilized with DPPG (DPPG-FLRes) to rat skin tissue, FLRes molecules infiltrated into the epidermis layer permeating stratum corneum.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X20951443

Reference12 articles.

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