Affiliation:
1. College of Pharmaceutical Sciences, Zhejiang University, 388 Yuhangtang Rd., Hangzhou, P. R. China 310058
Abstract
A new sesquiterpenoid, 1α,5α-epoxy-4α-hydroxyl-4β,10β-dimethyl-7αH,10αH-guaia-11(13)-en-12-oic acid (1), and four known compounds, lactucin (2), 1β-hydroxy-7αH,8,11βH-eudesm-3-en-8,12-olide (3), 13,14- seco-stigma 9(11),14(15)-dien-3α-ol (4), and bacosterol-3- O-β-D-glucopyranoside (5) were isolated from Cichorium intybus L. Their structures were determined on the basis of detailed analysis of their 1D- and 2D-NMR spectroscopic and mass spectrometric data. Compounds 2 and 4 showed strong activities against the A2780 cell line with IC50 values of 1.81 and 0.07 μM, respectively.
Subject
Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine
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