Anti-inflammatory and Gastroprotective Properties of Hypericum Richeri Oil Extracts-Reference-Cited by-同舟云学术

Anti-inflammatory and Gastroprotective Properties of Hypericum Richeri Oil Extracts

Published:2010-08 Issue:8 Volume:5 Page:1934578X1000500
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Zdunić Gordana¹,Gođevac Dejan²,Milenković Marina³,Šavikin Katarina¹,Menković Nebojša¹,Petrović Silvana⁴

Affiliation:

1. Institute for Medicinal Plant Research “Dr Josif Pančić”, Tadeuša Košćuška 1, 11000 Belgrade, Serbia

2. Institute of Chemistry, Technology and Metallurgy, University of Belgrade, Njegoševa 12, 11000 Belgrade, Serbia

3. Institute of Microbiology and Immunology, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, Serbia

4. Institute of Pharmacognosy, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, Serbia

Abstract

Oil extracts of flowering tops of Hypericum richeri Vill. prepared in three different ways were evaluated for chemical composition, and Anti-inflammatory and Gastroprotective activities. An HPLC method was developed for determination of two dominant flavonoids, quercetin and I3,II8-biapigenin. The carrageenan-induced rat paw edema test was used for screening the antiinflammatory activity, while indomethacin-induced rat gastric mucosa damage test was used for evaluation of gastroprotective activity. The oil extract prepared by maceration with 96% ethanol, followed by extraction with sunflower oil by heating on a water bath, exhibited the highest antiinflammatory (38.4 %) and gastroprotective activities (gastric damage score of 0.9). The same oil extract had the highest content of quercetin (49 μg/mL) and I3,II8-biapigenin (60 μg/mL). These results approve the usage of oil extracts of H. richeri as an antiinflammatory and gastroprotective agent.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1000500814

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