Polyketides from an Endophytic Aspergillus fumigatus Isolate Inhibit the Growth of Mycobacterium tuberculosis and MRSA-Reference-Cited by-同舟云学术

Polyketides from an Endophytic Aspergillus fumigatus Isolate Inhibit the Growth of Mycobacterium tuberculosis and MRSA

Published:2015-10 Issue:10 Volume:10 Page:1934578X1501001
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Flewelling Andrew J.¹,Bishop Amanda L²,Johnson John A.¹,Gray Christopher A.¹²

Affiliation:

1. Department of Biology, University of New Brunswick, 100 Tucker Park Rd, Saint John, NB, Canada, E2L 4L5

2. Department of Chemistry, University of New Brunswick, 30 Dineen Dr, Fredericton, NB, Canada, E3B 5A3

Abstract

The crude extract of Aspergillus fumigatus isolate AF3-093A, an endophyte of the brown algaFucus vesiculosus, showed significant antimicrobial activity in initial bioactivity screens. Bioassay-guided fractionation of the extract led to the isolation of flavipin, chaetoglobosin A and chaetoglobosin B, all of which inhibited the growth of Staphylococcus aureus, methicillin-resistant S. aureus and Mycobacterium tuberculosis H37Ra. The antimycobacterial activity of these compounds has not been previously reported.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1501001009

Reference20 articles.

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