Affiliation:
1. Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, China
2. Nanchang Key Laboratory of Pharmacology and Transformation Application of Traditional Chinese Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, China
3. Research and Development Department (R & D Department), Jiangzhong Pharmaceutical Co., Ltd, Nanchang, China
4. College of Life Sciences, Zhejiang University, Hangzhou, China
Abstract
Nine compounds were isolated from leaves of Dendrobium officinale, including 1 new bibenzyl derivative, denofficin (1), and 8 known structurally related compounds, dendrocandin B (2), dendrocandin U (3), 3,4-dihydroxy-5,4′-dimethoxy bibenzyl (4), moscatilin (5), 4,4′-dihydroxy-3,5-dimethoxy bibenzyl (6), ( S)-3,4,α-trihydroxy-5,4′-dimethoxy bibenzyl (7), gigantol (8), densiflorol A (9). The structures of these compounds were identified by spectroscopic methods. All isolated compounds were screened for their cytotoxicity against human cervical cancer cell line HeLa cells. Of them, compounds 1-3, 5, 6, and 8 were found to have the capabilities of proliferation inhibition against HeLa cells with half-maximal inhibitory concentration values ranging from 8.0 to 92.4 μM.
Funder
Scientific Foundation of Double World-classes Subject Development of Jiangxi University of Traditional Chinese Medicine
Foundation of Zhejiang Educational Committee
Subject of Nanchang Science and Technology Bureau
Subject
Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine
Cited by
17 articles.
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