Cytotoxic Compounds from the Stem Bark of Calophyllum soulattri-Reference-Cited by-同舟云学术

Cytotoxic Compounds from the Stem Bark of Calophyllum soulattri

Published:2017-09 Issue:9 Volume:12 Page:1934578X1701200
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Lim Chan-Kiang¹,Hemaroopini Subramaniam¹,Say Yee-How²,Jong Vivien Yi-Mian³

Affiliation:

1. Department of Chemical Science, Faculty of Science, Universiti Tunku Abdul Rahman, Jalan Universiti, Bandar Barat, 31900 Kampar, Perak, Malaysia

2. Department of Biomedical Science, Faculty of Science, Universiti Tunku Abdul Rahman, Jalan Universiti, Bandar Barat, 31900 Kampar, Perak, Malaysia

3. Centre for Applied Sciences, Faculty of Applied Sciences, Universiti Teknologi MARA, Samarahan Campus 2, Jalan Meranek, 94300 Kota Samarahan, Sarawak, Malaysia

Abstract

Chemical investigation of the stem bark of Calophyllum soulattri resulted in the isolation of a new phloroglucinol, namely calosubellinone (1) along with two known compounds, garsubellin B (2) and soulattrone A (3). The structures of these compounds were established on the basis of spectroscopic methods. Compounds 1 and 2 displayed growth inhibitory activities against HeLa cancer cells comparable to the positive control cisplatin, with IC50 values of 19.3 and 16.5 μM, respectively. In addition, compound 2 also showed antiproliferative activity against a MDA-MB-231 cancer cell line with an IC50 value of 17.7 μM. Compounds 1 and 2 were found to exhibit good cancer-specific cytotoxicity when tested against noncancerous HEK293 cells. These findings have highlighted the therapeutic potential of compounds 1 and 2 as anticancer agents.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1701200922

Reference13 articles.

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