A New Bioactive Sesquiterpenoid Quinone from the Mediterranean Sea Marine Sponge Dysidea avara-Reference-Cited by-同舟云学术

A New Bioactive Sesquiterpenoid Quinone from the Mediterranean Sea Marine Sponge Dysidea avara

Published:2013-03 Issue:3 Volume:8 Page:1934578X1300800
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Hamed Ashraf Nageeb El-Sayed¹²,Wätjen Wim³⁴,Schmitz Roland³,Chovolou Yvonni³,Edrada-Ebel RuAngelie⁵,Youssef Diaa T. A.⁶,Kamel Mohammed Salah²,Proksch Peter¹

Affiliation:

1. Institut für Pharmazeutische Biologie und Biotechnologie, Heinrich-Heine-Universität, Universitätsstrasse 1, Geb. 26.23, 40225 Düsseldorf, Germany

2. Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt

3. Institut für Toxikologie, Postfach 101007, Heinrich-Heine-Universität, 40001 Düsseldorf, Germany

4. Martin-Luther-University Halle-Wittenberg, Faculty III, Institute of Agriculture and Food Science, Weinbergweg 22, 06120 Halle/Saale, Germany

5. Strathclyde Institute of Pharmacy and Biomedical Science, Strathclyde University, The John Arbuthnott Building, 27 Taylor Street, Glasgow G4 0NR, United Kingdom

6. Department of Natural Products, Faculty of Pharmacy, King Abdulaziz University, Jeddah, 21589, Kingdom of Saudi Arabia

Abstract

Investigation of the marine sponge Dysidea avara, family Dysideidae, afforded a new sesquiterpene (-)- N-methylmelemeleone-A (5), in addition to four known sesquiterpenes (+)-avarol (1), (+)-avarone (2), (-)-3′-methylaminoavarone (3) and (-)-4′-methylaminoavarone (4). The structure elucidation of compound 5 was based on 1D and 2D NMR spectroscopic, and HR-MS studies, as well as by comparison with the literature. Cytotoxicity, protein kinase inhibition, inhibition of NFkB-activity and insecticidal activity were evaluated for the isolated compounds.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1300800303

Reference18 articles.

1. A new sesquiterpene from the sponge

2. Evaluation of new sesquiterpene quinones from two Dysidea sponge species as inhibitors of protein tyrosine kinase

3. Differential modulation of host cell and hiv gene expression by combinations of avarol and AZT in vitro

4. Sesquiterpene Furans and Thiosesquiterpenes from the Nudibranch Ceratosoma brevicaudatum

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