Monanchomycalin C, a New Pentacyclic Guanidine Alkaloid from the Far-Eastern Marine Sponge Monanchora Pulchra-Reference-Cited by-同舟云学术

Monanchomycalin C, a New Pentacyclic Guanidine Alkaloid from the Far-Eastern Marine Sponge Monanchora Pulchra

Published:2013-10 Issue:10 Volume:8 Page:1934578X1300801
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Tabakmakher Ksenya M.¹,Denisenko Vladimir A.¹,Guzii Alla G.¹,Dmitrenok Pavel S.¹,Dyshlovoy Sergey A.¹,Lee Hyi-Seung²,Makarieva Tatyana N.¹

Affiliation:

1. G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch, Russian Academy of Sciences, Vladivostok-22, Prospect 100-let Vladivostoku 159, Russia

2. Korea Institute of Ocean Science & Technology, Marine Natural Products Laboratory, Ansan 426-744, Republic of Korea

Abstract

A new pentacyclic guanidine alkaloid, monanchomycalin C (1), along with the earlier known ptilomycalin A (2), were isolated from the Far-Eastern marine sponge Monanchora pulchra. The structure of 1 was elucidated using 1D and 2D NMR spectroscopic and mass spectrometric data. Compounds 1 and 2 exhibited cytotoxic activities against human breast cancer MDA-MB-231 cells with IC50 values of 8.2 μM and 4.3 μM, respectively.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1300801014

Reference36 articles.

1. Natural guanidine derivatives

2. Natural guanidine derivatives

3. The chemistry and biology of organic guanidine derivatives

4. The chemistry and biology of organic guanidine derivatives

5. The chemistry and biology of organic guanidine derivatives

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