Ganoderic Acid TR, a New Lanostanoid with 5α-Reductase Inhibitory Activity from the Fruiting Body of Ganoderma Lucidum-Reference-Cited by-同舟云学术

Ganoderic Acid TR, a New Lanostanoid with 5α-Reductase Inhibitory Activity from the Fruiting Body of Ganoderma Lucidum

Published:2006-05 Issue:5 Volume:1 Page:1934578X0600100
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Liu Jie¹,Shimizu Kuniyoshi¹,Kondo Ryuichiro¹

Affiliation:

1. Department of Forest and Forest Products Science, Faculty of Agriculture, Kyushu University, Fukuoka, 812-8581, Japan

Abstract

By means of 5α-reductase inhibitory activity-guided fractionation, a new lanostanoid, 15α-hydroxy-3-oxolanosta- 7, 9(11), 24(E)-trien-26-oic acid, named as ganoderic acid TR, was isolated from the ethanol extract of the fruiting bodies of Ganoderma lucidum (Fr.) Karst (Ganodermataceae). The compound showed potent inhibitory activity with an IC50 of 8.5 μM. Modified Mosher's method established the S-configuration of the secondary hydroxyl group at C-15. In addition, a carboxyl group on the side chain of ganoderic acid TR is essential to elicit the inhibitory activity because of the considerably lower activity of its methyl ester.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X0600100501

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