Absence of mutagenic activity in the bacterial reverse mutation assay with pulegone and peppermint oil-Reference-Cited by-同舟云学术

Absence of mutagenic activity in the bacterial reverse mutation assay with pulegone and peppermint oil

Published:2020-01-01 Issue: Volume:4 Page:239784732093866
ISSN:2397-8473
Container-title:Toxicology Research and Application
language:en
Short-container-title:Toxicology Research and Application

Author:

Bastaki Maria¹,Lu Vivian¹,Aubanel Michel²,Bialk Heidi³,Choi Christopher⁴,Demyttenaere Jan⁵,Diop Maodo Malick⁶,Etter Sylvain⁷,Han Xing⁸,Harman Christie L⁹,Krammer Gerhard¹⁰,Schnabel Jürgen¹¹,Wilson Cody L¹²,Taylor Sean V¹^ORCID

Affiliation:

1. International Organization of the Flavor Industry, Washington, DC, USA

2. Kerry Flavours France, Grasse, France

3. PepsiCo Inc., Valhalla, NY, USA

4. Takasago International Corporation, Rockleigh, NJ, USA

5. European Flavour Association, Brussels, Belgium

6. V. Mane Fils, Le Bar-sur Loup, France

7. Firmenich International SA, Meyrin, Switzerland

8. International Flavors & Fragrances Inc., Hazlet, NJ, USA

9. Flavor and Extract Manufacturers Association, Washington, DC, USA

10. Symrise AG, Holzminden, Germany

11. Givaudan International SA, Kemptthal, Switzerland

12. The Coca-Cola Company, Atlanta, GA, USA

Abstract

The essential oil of peppermint and one of its natural constituents, (R)-(+)-pulegone, are approved flavorings added to food worldwide. (R)-(+)-Pulegone and peppermint oil were tested separately in two independent bacterial reverse mutation assays according to Organisation for Economic Co-operation and Development Guideline 471. Both flavorings did not produce any evidence of mutagenicity up to cytotoxic concentrations in either the presence or the absence of exogenous metabolic activation.

Funder

International Organization of the Flavor Industry

Publisher

SAGE Publications

Link

http://journals.sagepub.com/doi/pdf/10.1177/2397847320938666

Reference27 articles.

1. Tucker AO, DeBaggio T. The big book of herbs: a comprehensive illustrated reference to herbs of flavor and fragrance. Loveland, CO: Interweave Press, 2000, p. 688.

2. Plants of Genus Mentha: From Farm to Food Factory

3. (−)-Menthol biosynthesis and molecular genetics

4. Lawrence BM. Peppermint oil . Carol Stream, IL: Allured Publishing Corp, 2008.

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. RIFM fragrance ingredient safety assessment, pulegone, CAS Registry Number 89-82-7;Food and Chemical Toxicology;2021-03