Retrospective analysis of adverse effects associated with pyrethrins-containing products

Author:

Osimitz Thomas G1ORCID,Sioris Kelly23,Gualtieri John23,Filandrinos Dean23,Seaverson Ryan2,Carlson Angeline M4,Droege Wiebke1ORCID,Kingston Rick235

Affiliation:

1. Science Strategies, LLC, Charlottesville, VA, USA

2. SafetyCall International, LLC, Minneapolis, MN, USA

3. Department of Experimental and Clinical Pharmacology (ECP), College of Pharmacy, University of Minnesota, Minneapolis, MN, USA

4. Data Intelligence Consultants LLC, Eden Prairie, MN, USA

5. Division of Professional Education, College of Pharmacy, University of Minnesota, Minneapolis, MN, USA

Abstract

The Pyrethrins Stewardship Program (PSP) was established to better understand adverse effects following exposure to pyrethrins-containing insecticide products. Running from April 2010 through December 2016, symptomatic dermal and inhalation exposures were entered into Phase I of the PSP and analyzed for exposure details and nature of the effects reported. Phase II consisted of an in-depth telephone interview using an enhanced questionnaire to investigate additional exposure details. Phase III scored the association between exposure and reported effects. Based on the data collected and analyzed, we conclude that: (1) Both in absolute number and relative to the wide distribution and use by consumers, adverse respiratory or dermal events after product exposure were rare; (2) Most outcomes for the reported events involving either dermal or respiratory effects were of minor severity and self-limiting; (3) None of the data collected and analyzed indicate that pyrethrins-containing products, including those formulated with synthetic pyrethroids and/or synergists, pose a significant risk of serious dermal or respiratory reactions even in cases where the exposed individual reported having allergies or asthma; (4) No additional label warnings or other mitigation techniques are warranted with pyrethrins-containing products formulated with or without synthetic pyrethroids and/or synergists.

Funder

Pyrethrin Joint Venture

Publisher

SAGE Publications

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