Insulin Resistance in children on Sodium Valproate – A hospital based cross-sectional study in Indian children

Author:

George Lydia James12,Singh Preeti3ORCID,Aneja Satinder4,Singh Ritu5,Solanki RS6,Seth Anju7ORCID

Affiliation:

1. MD, Senior Resident, Department of Pediatrics, LHMC, New Delhi, India

2. MD (Pediatrics), Assistant Professor, Department of Pediatric Cardiology, Trivandrum Medical College, Trivandrum, India

3. MD (Pediatrics), Associate Professor, Department of Pediatrics, Lady Hardinge Medical College, New Delhi, India

4. MD (Pediatrics), Rtd, Former Director Professor and Head, Department of Pediatrics, Lady Hardinge Medical College (LHMC), New Delhi, India

5. MD (Biochemistry), Director- Professor and Head, Department of Biochemistry, Lady Hardinge Medical College (LHMC), New Delhi, India

6. MD (Radio-diagnosis), Director- Professor and Head, Department of Radio- Diagnosis, Lady Hardinge Medical College (LHMC), New Delhi, India

7. MD (Pediatrics), Director- Professor, and Head Department of Pediatrics, Lady Hardinge Medical College (LHMC), New Delhi, India

Abstract

Our objective was to compare the point prevalence of insulin resistance (IR) in children taking sodium valproate (VPA) and phenytoin sodium (PS) monotherapy for >1 year. 150 children, aged 6–18 years, were categorized (50 each) into - group A (VPA), group B (PS) and group C (healthy controls age-sex matched with group A). Groups were compared for metabolic complications and risk factors assessed. The point prevalence of IR and non-alcoholic fatty liver disease was significantly higher in children on VPA (12% and 34% respectively) than on PS and healthy controls, regardless of age, sex, pubertal and nutritional status. The presence of central obesity, acanthosis, hypertension, dyslipidaemia was significantly associated with IR but none showed an independent association on multivariate analysis. Therapy with VPA makes children susceptible to metabolic complications. Close monitoring will facilitate early detection and timely intervention.

Publisher

SAGE Publications

Subject

Infectious Diseases,Public Health, Environmental and Occupational Health

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