The Use of Misoprostol for Mid-Trimester Therapeutic Termination of Pregnancy

Author:

Munthali J1,Moodley J2

Affiliation:

1. Department of Obstetrics & Gynaecology, University of Natal Medical School, Private Bag 7 Congella 4013, Durban, South Africa

2. Department of MRC/UN Pregnancy Hypertension Research Unit, University of Natal Medical School, Private Bag 7 Congella 4013, Durban, South Africa

Abstract

Extra-amniotic prostaglandin F2α (PG F2α) is probably the most widely used medical method for mid-trimester termination of pregnancy. The method is highly effective but is financially costly, particularly for poor countries faced with restricted health budgets. The aim of this study was to establish whether misoprostol administered vaginally is as effective as PG F2α. Sixty-one patients were prospectively randomized to receive either misoprostol ( n=30) vaginally, or PG F2α ( n=31) extra-amniotically. The overall success rate was 83.6%. The success rates in the misoprostol and PG F2α groups were 83.3% and 83.8% respectively. There was no statistical difference in the groups in relation to side effects. In this carefully selected group of patients, misoprostol was as safe and effective as PG F2α in mid-trimester termination of pregnancy. In these days of financial constraints, misoprostol is the preferred method for mid-trimester termination of pregnancy.

Publisher

SAGE Publications

Subject

Infectious Diseases,Public Health, Environmental and Occupational Health

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