Utility of rapid chromatographic Immunoassay to rule out typhoid Fever among malaria negative patients

Author:

Kashyap Bineeta1ORCID,Nirmal Kirti1ORCID

Affiliation:

1. Department of Microbiology, University College of Medical Sciences and Guru Tag Bahadur Hospital, Dilshad Garden, Delhi. 110095

Abstract

Enteric fever, an endemic disease, is a significant health problem in developing low- and middle-income countries (LMICs). We studied the utility of Typhoid IgM/IgG assay in Widal titre positive samples among malaria negative patients. A total of 30 febrile patients were included. A blood sample was collected for performing the Widal test and a rapid lateral flow immune assay (Typhoid IgG/IgM tests). A total of 13/30 were positive on blood culture; however, Salmonella typhi grew on only two (6.6%). Of the 30 samples, 24 (80%) were positive for the rapid immunochromatographic (ICT) test None of the samples negative by the rapid ICT test grew Salmonella typhi. The rapid ICT test has better sensitivity and is easy to perform with minimal infrastructure; hence, it is a practical alternative to the age old Widal test

Publisher

SAGE Publications

Subject

Infectious Diseases,Public Health, Environmental and Occupational Health

Reference16 articles.

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2. Evaluation of new-generation serologic tests for the diagnosis of typhoid fever: data from a community-based surveillance in Calcutta, India

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