Prevention and Treatment of Serous Otitis Media with an Oral Antihistamine

Author:

Klein Suzanne W.1,Olson Ardis L.1,Perrin James1,Cunningham David1,Hengerer Arthur1,Hoekelman Robert A.1,Roghmann Klaus J.1

Affiliation:

1. General Pediatrics Division, Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York

Abstract

Serous otitis media (SOM) is a common and troublesome disease in childhood. Although antihistamines are commonly prescribed to prevent or treat SOM, there have been no controlled clinical trials to determine the efficacy of such interventions. This study was designed to determine if antihistamines are of value in the prevention or treatment of SOM. Using a randomized double-blind method, 206 children with acute otitis media were treated with antibiotics and either brompheniramine maleate or placebo. The children were evaluated two weeks later by tympanometry and, independently, by combined pneumatoscopy and otoscopy. There were no significant differences overall between the treatment and control groups in terms of preventing SOM: 44% of those on antihistamine and 41 % of those on placebo had SOM after two weeks of therapy. However, children with a history of serous otitis media did signifi cantly better on placebo than did those on antihistamine, and children without a history of serous otitis media did significantly better on antihistamine than did those on placebo. One hundred children continued to use antihistamine or placebo for four more weeks. There were no significant differences between the treatment and control groups in terms of resolution of SOM (64% versus 68%).

Publisher

SAGE Publications

Subject

Pediatrics, Perinatology, and Child Health

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1. Otitis media with effusion: benefits and harms of strategies in use for treatment and prevention;Expert Review of Anti-infective Therapy;2016-02-26

2. Acute Otitis Media and Otitis Media with Effusion;Cummings Pediatric Otolaryngology;2015

3. Antihistamines and/or decongestants for otitis media with effusion (OME) in children;Cochrane Database of Systematic Reviews;2011-09-07

4. Decongestants and antihistamines for acute otitis media in children;Cochrane Database of Systematic Reviews;2011-03-16

5. Acute Otitis Media and Otitis Media with Effusion;Cummings Otolaryngology - Head and Neck Surgery;2010

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