Candida Endocarditis and Encephalitis in an Infant

Abstract

A one-month-old infant with chronic diarrhea, staphylococcus septicemia, otitis, mastoiditis, and malnutrition was treated by intravenous alimentation and multiple antibiotics. He developed an abscess at the site of an intrajugular indwelling plastic catheter, from which Candida was grown. He died suddenly with signs of endocarditis with embolization. Autopsy revealed disseminated candidiasis, endocarditis with large candidal vegetations on all valves, with multiple granulomata and microabscesses in the brain. The possible role of indwelling plastic catheters, mastoiditis, malnutrition, and antibiotics in the pathogenesis of disseminated candidiasis in infants is discussed. Candida endocarditis is very rare in children, and this case is the fourth to be reported in the literature.