Prophylactic Cryoprecipitate in Congenital Afibrinogenemia

Author:

Rodriguez Raul C.1,Buchanan George R.1,Clanton Mark S.1

Affiliation:

1. Department of Pediatrics, The University of Texas Southwestern Medical Center at Dallas and Children's Medical Center, Dallas, Texas

Abstract

Two siblings with congenital afibrinogenemia received prophylactic infusions of cryoprecipitate in order to prevent serious hemorrhage during early childhood. Three bags (units) of this fibrinogen-containing blood product were administered every 7-10 days for 15 months in one case and 24 months in the other. Hemorrhage was nearly completely prevented during the period of prophylaxis. Side effects from cryoprecipitate were not observed. Prophylactic infusion of cryoprecipitate, made practical by the relatively long half-life of fibrinogen, should be considered in other patients with this disorder.

Publisher

SAGE Publications

Subject

Pediatrics, Perinatology and Child Health

Cited by 19 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Clinical guidelines for cryoprecipitate transfusions;Russian journal of hematology and transfusiology;2020-03-11

2. A RARE CASE REPORT: CONGENITAL HYPOFIBRINOGENAEMIA - A NEWBORN INFANT WITH CORD BLEEDING;Journal of Evolution of Medical and Dental Sciences;2016-10-10

3. Umbilical bleeding;Blood Coagulation & Fibrinolysis;2015-10

4. Guideline for the diagnosis and management of the rare coagulation disorders;British Journal of Haematology;2014-08-06

5. Fibrinogen replacement therapy for congenital fibrinogen deficiency;Journal of Thrombosis and Haemostasis;2011-09

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