Early Clinical Evaluation of Coronary Artery Lesions in Kawasaki Disease

Author:

Shu Zhongyu12ORCID,Deng Fang1ORCID,Yang Shuxinying3

Affiliation:

1. Department of Pediatrics, Affiliated Provincial Children’s Hospital, Anhui Medical University, Hefei, China

2. Department of Internal Medicine, Children’s Hospital Affiliated to Anhui Medical University, Hefei, China

3. The Southern District Laboratory Department, The First Affiliated Hospital of the University of Science and Technology of China, Hefei, China

Abstract

The purpose of this study is to analyze the early clinical features of coronary artery lesion (CAL) in Kawasaki disease (KD), evaluate systemic inflammation indicators, and enhance early recognition of CAL in the acute phase of KD. A total of 314 children with KD were divided into those with CAL (CAL group) and without CAL (NCAL group) using echocardiographic results, and their clinical data were retrospectively analyzed. For KD patients, male, children aged 3 to 9 years, and those with fever longer than 6 days before intravenous immunoglobulin (IVIG) use were more likely to have CAL. There were significant differences in sex, age, and fever time ( P < .05). Moreover, some laboratory indicator test results revealed there was a significant difference between N-terminal pro-brain natriuretic peptide (NT-pro-BNP) and interleukin-6 (IL-6), and the CAL ( P < .05). This study has certain guiding significance for early clinical evaluation.

Funder

Anhui Medical University Fund project

Publisher

SAGE Publications

Subject

Pediatrics, Perinatology and Child Health

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