Affiliation:
1. From the Department of Pediatrics, State University of New York, Upstate Medical Center, Syracuse, New York
Abstract
In some children, psychological events have appeared to be important in the triggering of Graves' disease. This report examines the case histories of three children in whom the appearance of symptomatology of Graves' disease was associated with depression following the death of a loved one. An analysis of neuroendocrine and immunologic pathways suggests that depression, set off by bereavement, causes low levels of norepinephrine in the brain. The latter in turn may mediate an increase in ACTH and cortisol, leading to reductions in immune surveillance and resultant production of thyroid-stimulating immuno globulins, hence the development of Graves' disease.
Subject
Pediatrics, Perinatology and Child Health
Reference30 articles.
1. Parry HC: Collected Works, Volume I. London, Underwood, 1825, p 478
2. Weiner HM: Psychobiology and Human Disease. New York, Elsevier, 1977, p 319
3. A Review of Psychoendocrine Research on the Pituitary-Thyroid System
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