Evaluation of Occult Acetaminophen Hepatotoxicity in Hospitalized Children Receiving Acetaminophen-Reference-Cited by-同舟云学术

Evaluation of Occult Acetaminophen Hepatotoxicity in Hospitalized Children Receiving Acetaminophen

Published:2001-05 Issue:5 Volume:40 Page:243-248
ISSN:0009-9228
Container-title:Clinical Pediatrics
language:en
Short-container-title:Clin Pediatr (Phila)

Author:

James Laura P.¹,Wilson John T.,Simar Renee²,Farrar Henry C.¹,Kearns Gregory L.³,Simpson Pippa M.⁴,Hinson Jack A.,Pumford Neil R.⁵,

Affiliation:

1. Department of Pediatrics, Section of Pediatric Clinical Pharmacology and Toxicology, University of Arkansas for Medical Sciences and Arkansas Children's Hospital, Little Rock, AR

2. Department of Pediatrics, Section on Clinical Pharmacology, Louisiana State University School of Medicine, Shreveport, LA

3. Departments of Pediatrics and Pharmacology, University of Missouri-Kansas City, Section of Pediatric Clinical Pharmacology and Experimental Therapeutics, Mercy Children's Hospital, Kansas City, MO

4. Department of Pediatrics, Center for Applied Research and Evaluation, University of Arkansas for Medical Sciences and Arkansas Children's Hospital, Little Rock, AR

5. Departments of Pediatrics, Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR

Abstract

The safety of repeated doses of acetaminophen in ill children with the potential of reduced glutathione stores has been questioned. This study measured hepatic transaminases in children and adolescents (n=100) who received >6 therapeutic doses of acetaminophen over a 48-hour period of hospitalization. Acetaminophen-protein adducts were measured in a cohort of subjects with hepatic transaminase elevation (n=8) and in those (n=10) receiving concurrent drug therapy with agents that induce the cytochrome P450 enzymes involved in acetaminophen metabolism. Acetaminophen-protein adducts were not detected in this cohort of 18 subjects. Based on this pilot study, the routine use of acetaminophen at therapeutic doses in ill, hospitalized children and adolescents appears safe.

Publisher

SAGE Publications

Subject

Pediatrics, Perinatology and Child Health

Link

http://journals.sagepub.com/doi/pdf/10.1177/000992280104000501

Reference28 articles.

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4. Acetaminophen Toxicity in an Urban County Hospital

5. Enhanced Hepatotoxicity of Acetaminophen in the Alcoholic Patient: Two Case Reports and a Review of the Literature

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