Affiliation:
1. Department of Pediatrics, State University of New York Health Science Center at Brooklyn and Children's Medical Center of Brooklyn, Brooklyn, NY 11203
Abstract
We describe a patient with leukemia in remission for 7 years who developed growth hormone (GH) deficiency and was treated with recombinant human growth hormone (rhGH). We compare her growth with that of patients from the National Cooperative Growth Study (NCGS) database, 145 with leukemia in remission and 725 with idiopathic growth hormone deficiency (IGHD) on treatment with rhGH. We also review the literature on the risk of relapse of leukemia in similar patients. The patients with leukemia in remission from the NCGS database had a significantly lower change of mean height standard deviation score than that of IGHD patients in the first, second, and third year of rhGH treatment. The relapse rate of leukemia in patients treated with rhGH is between 0.8% and 2%. Starting rhGH therapy in patients with leukemia in remission and with GH deficiency at an adequate dosage and without undue delay would improve their growth response. Such therapy does not appear to increase the risk of leukemia.
Subject
Pediatrics, Perinatology and Child Health
Reference23 articles.
1. Childhood cancer
2. 4. Pizzo PA, Poplock DB, eds. Principles and Practice of Pediatric Oncology. Philadelphia: Lippincott; 1989:323-382.
3. Dose dependency of time of onset of radiation-induced growth hormone deficiency
Cited by
8 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献