Affiliation:
1. The Mary Imogene Bassett Hospital, Cooperstown, New York
Abstract
The formation of serum albumin in chicken liver has been shown to proceed via an intermediate stage in which newly formed albumin is bound to microsomes. This bound albumin is apparently formed within 2-3 minutes, but its release requires 15-20 minutes and is readily blocked by metabolic inhibitors. Comparison of the effectiveness of various agents in releasing this newly formed albumin suggests that the albumin is bound on or in the lipide-rich membrane of the microsome. After release by desoxycholate the material is indistinguishable from native serum albumin in its physical and chemical properties. The mechanisms of the synthesis of proteins in liver are discussed, and insofar as possible related to the results with serum albumin.
Cited by
51 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. N-TERMINAL AMINO ACID SEQUENCE OF PROALBUMIN FROM INBRED BUFFALO RATS;International Journal of Peptide and Protein Research;2009-01-12
2. SUBCELLULAR LOCALIZATION OF MELANIN BIOSYNTHESTS;Annals of the New York Academy of Sciences;2006-12-15
3. Conservation of Digestive Enzymes;Physiological Reviews;2002-01-01
4. Bibliography;All About Albumin;1995
5. Serum Albumin: Adventures of a Circulating Protein;The Impact of Protein Chemistry on the Biomedical Sciences;1984