Affiliation:
1. Department of Cell and Gene Research, Arizona Heart Institute and Foundation, Phoenix, Arizona, USA
Abstract
Advances in catheter technology, gene identification, and cell biology may provide novel treatment options for patients with peripheral arterial disease (PAD) who are not candidates for standard revascularization procedures. Animal studies and recent results in human beings suggest that transfer of growth factors or regulatory genes and transplantation of progenitor cells may provide novel therapy options by inducing therapeutic angiogenesis or by inhibiting restenosis. This review will discuss the development of a variety of catheters for localized endovascular delivery, as well as the various cellular and genetic strategies that exist to restore blood flow to ischemic tissue and to reduce neointimal hyperplasia.
Subject
Cardiology and Cardiovascular Medicine,Radiology Nuclear Medicine and imaging,Surgery
Cited by
7 articles.
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