A review of the therapeutic management of ulcerative colitis

Author:

Aslam Nasar1,Lo Sheng Wei2,Sikafi Rafid3,Barnes Tom4,Segal Jonathan56ORCID,Smith Philip J7,Limdi Jimmy K89ORCID

Affiliation:

1. Department of Gastroenterology, University College London Hospitals, 235 Euston Road, London, NW1 2BU, UK

2. Northern Hospital, Epping, VIC, Australia

3. St Mark’s Hospital, London North West University Healthcare NHS Trust, London, UK

4. Section of IBD – Division of Gastroenterology, Northern Care Alliance NHS Foundation Trust, Salford, UK

5. Northern Hospital, Epping, Melbourne, VIC, Australia

6. Department of Medicine, University of Melbourne, Parkville, VIC, Australia

7. Department of Gastroenterology, Royal Liverpool Hospital, Liverpool University Hospitals Foundation NHS Trust, Liverpool, UK

8. Section of IBD – Division of Gastroenterology, Northern Care Alliance NHS Foundation Trust, Manchester, UK

9. Manchester Academic Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK

Abstract

Ulcerative colitis (UC) is a chronic relapsing and remitting gastrointestinal disorder of uncertain aetiology. The last two decades have seen an expansion in the therapeutic arsenal used to treat UC. This has resulted in improved clinical remission and response rates. Nonetheless, staples in our current medical management originate from trials conducted in the early 20th century. In this review article, we aim to outline the key milestones in the history of the medical management of UC in addition to highlighting promising therapeutic developments for the future.

Publisher

SAGE Publications

Subject

Gastroenterology

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