Antimicrobial Property of a Herbal Preparation Containing Dalbergia Sissoo and Datura Stramonium with Cow Urine against Pathogenic Bacteria

Author:

Yadav H.1,Yadav M.2,Jain S.3,Bhardwaj A.4,Singh V.5,Parkash O.6,Marotta F.7

Affiliation:

1. Subhash Chandra Bose College of Professional Studies, Gwalior

2. SOS in Chemistry, Jiwaji University, Gwalior, India

3. Department of Food Science and Human Nutrition, University of Illinois, Urbana, IL, USA

4. Meerut Institute of Engineering and Technology, Meerut, U.P., India

5. Department of Microbiology, Barkatullah University, Bhopal, M.P., India

6. National JALMA Institute for Leprosy and Other Mycobacterial Diseases, Agra, U.P., India

7. Nutraceutical-Nutragenomic Unit, GAIA Foundation, Milan, Italy

Abstract

In this study, a herbal preparation containing Dalbergia sissoo and Datura stramoium with cow urine (DSDS), was evaluated for its antibacterial potential against pathogenic strains of gram-positive ( Staphylococcus aureus and Streptococcus pneumoniae) and gram-negative ( Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumoniae) bacteria. Antibacterial activity was compared to standard antibiotic drugs i.e. Chloramphenicol (30 mcg), Ampicillin (10 mcg), Nalidixic acid (10 mcg) and Rifampicin (30 mcg). Cow urine extract was found to be most active against both gram-positive as well as gram-negative bacteria. Clinical isolate of S. aureus showed higher sensitivity towards cow urine extract of DSDS than standard strains, and inhibited growth on most regulatory levels such as inhibition of protein, DNA, RNA and peptidoglycan synthesis. The results of the present study shows that the cow urine extract of DSDS may be used as a potent antiseptic preparation for prevention and treatment of chronic bacterial infections.

Publisher

SAGE Publications

Subject

Pharmacology,Immunology,Immunology and Allergy

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