Systemic Lupus Erythematosus: Immunopathogenesis and Novel Therapeutic Targets-Reference-Cited by-同舟云学术

Systemic Lupus Erythematosus: Immunopathogenesis and Novel Therapeutic Targets

Published:2013-07 Issue:3 Volume:26 Page:585-596
ISSN:2058-7384
Container-title:International Journal of Immunopathology and Pharmacology
language:en
Short-container-title:Int J Immunopathol Pharmacol

Author:

Beccastrini E.¹,D'Elios M.M.¹²,Emmi G.²,Silvestri E.¹²,Squatrito D.¹²,Prisco D.¹²,Emmi L.¹

Affiliation:

1. SOD Medical Pathology, Center for Autoimmune Systemic Diseases, Behçet Center and Lupus Clinic, AOU Careggi, Florence, Italy

2. Department of Experimental and Clinical Medicine, University of Florence, Italy

Abstract

Systemic lupus erythematosus (SLE) is the prototype of autoimmune diseases with multiorgan involvement. SLE presents many genetic and epigenetic associations and the pathogenesis is characterized by a complex network of alterations affecting both adaptative and innate immunity. The disclosure of novel mechanisms of SLE pathogenesis suggested new therapeutic targets, based on interference with the cytokine pathways or on depletion of the immune cells.

Publisher

SAGE Publications

Subject

Pharmacology,Immunology,Immunology and Allergy

Link

http://journals.sagepub.com/doi/pdf/10.1177/039463201302600302

Reference35 articles.

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