Affiliation:
1. Department of Laboratory Diagnostics, II Chair of Internal Medicine, Medical University of Lodz, Poland
2. Department of Internal Medicine, II Chair of Internal Medicine, Medical University of Lodz, Poland
Abstract
The study aimed to detect CD8 +CD25 +FoxP3brigh Tregs and investigate their possible association with selected lung function values. CD8+CD25+FoxP3brigh Tregs were detected by flow cytometry in the peripheral blood of 25 patients with severe asthma (SA), 25 patients with mild-to-moderate asthma (MA), and 25 age-matched healthy donors (NC). The percentages of CD8+CD25+FoxP3brigh Tregs of the patients with severe (3.4 ± 4.55), and mild-to-moderate asthma (7.5 ± 8.15), were markedly lower than those of controls (12.1 ± 13.2). The mean forced expiratory volume in 1 s (FEV1) % predicted value in severe asthma subpopulation was significantly lower (67.05 ± 15.98%) when compared with that of mild-to-moderate asthma subgroup (87.71 ± 16.12%). Interestingly, the percentages of CD8+CD25+FoxP3brigh Tregs correlate with mean peak expiratory flow (PEF)% predicted values in severe (r = 0.7, P <0.01) and mild-to-moderate (r = 0.73, P <0.01) asthma. In contrast, this parameter was positively correlated with FEV1% predicted values in the severe asthmatics only (r = 0.71, P <0.01). In summary, this study establishes a link between the percentage of CD8+CD25+FoxP3brigh Tregs and selected lung function parameters, suggesting that this parameter has potential as a marker for inflammation and airflow obstruction.
Subject
Pharmacology,Immunology,Immunology and Allergy
Cited by
15 articles.
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