Allergic Inflammation: Role of Cytokines with Special Emphasis on IL-4-Reference-Cited by-同舟云学术

Allergic Inflammation: Role of Cytokines with Special Emphasis on IL-4

Published:2011-04 Issue:2 Volume:24 Page:305-311
ISSN:2058-7384
Container-title:International Journal of Immunopathology and Pharmacology
language:en
Short-container-title:Int J Immunopathol Pharmacol

Author:

Saggini A.¹,Maccauro G.²,Tripodi D.³,De Lutiis M.A.⁴,Conti F.⁵,Felaco P.⁴,Fulcheri M.⁶,Galzio R.⁷,Caraffa A.⁸,Antinolfi P.⁸,Felaco M.⁵,Pandolfi F.⁹,Sabatino G.¹⁰,Neri G.¹¹,Shaik-Dasthagirisaheb Y.B.¹²

Affiliation:

1. Department of Dermatology, University of Rome Tor Vergata, Rome, Italy

2. Department of Orthopaedics, Catholic University of Rome, Rome, Italy

3. School of Dentistry, University of Chieti, Italy

4. Department of Human Dynamics, University of Chieti, Italy

5. Gynecology Division, Vasto Hospital, Vasto, Italy

6. Department of Clinical Psychology, University of Chieti, Italy

7. Department of Health Sciences, University of L'Aquila, Italy

8. Orthopaedics Division, University of Perugia, Perugia, Italy

9. Institute of Internal Medicine, Catholic University, Rome, Italy

10. Neonatology Division, University of Chieti, Italy

11. Department of ORL, University of Chieti, Chieti, Italy

12. Department of Medicine, Boston University School of Medicine, Boston, MA, USA

Abstract

This review examines recent articles on the relationship of cytokines to allergy and inflammation with particular emphasis on interleukin (IL)-4. The objective of this article is therefore to review published studies to identify cytokines consistently involved in allergic inflammation. Proinflammatory cytokines, including IL-4, IL-5, IL-13 and GM-CSF along with TNF-alpha play a role in allergen-induced airway leukocyte recruitment and these cytokines can be generated by T mast cells and other cells. In addition, IL-9, IL-25, IL-33, IL-17, IL-27 and IFN-γ are deeply involved in the regulation of asthma. Blocking the effect of these proinflammatory cytokines might provide new therapeutic approaches for the control of allergy and inflammation.

Publisher

SAGE Publications

Subject

Pharmacology,Immunology,Immunology and Allergy

Link

http://journals.sagepub.com/doi/pdf/10.1177/039463201102400204

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