Discrete MBL-MASP Complexes Show Wide Inter-Individual Variability in Concentration: Data from UK vs Armenian Populations

Author:

Mayilyan K.R.12,Presanis J.S.1,Arnold J.N.1,Sim R.B.1

Affiliation:

1. MRC Immunochemistry Unit, Department of Biochemistry, Oxford University, Oxford, UK

2. Institute of Molecular Biology, Armenian National Academy of Sciences, Yerevan, Armenia

Abstract

Mannan-binding lectin (MBL) circulates in plasma in complex with MBL-associated serine proteases (MASP) −1, −2 and −3 and a smaller component, MAp19. When MBL binds to the surface of foreign material (microorganisms), MASP-1, −2, −3 are activated. MASP-2 then activates the complement system. MASP-1 and −3 may activate other (unidentified) systems. MBL levels, MBL-bound MASP-1 and MBL-bound MASP-2 activities have been evaluated in healthy individuals from UK and Armenian populations. MBL-bound MASP-2 activity declines in aging (p<0.04). MBL correlates with smoking (p<0.02). There were significant differences between the two populations in MBL-bound MASP-1 activity and in MBL, but no difference in MBL-bound MASP-2 activity. When MASP activities were normalised to MBL (i.e. MASP-1 activity/MBL, MASP-2 activity/MBL), normalised MASP-2 activity in UK individuals was more than 2 fold higher than in Armenians. The difference in normalised MASP-2 activity level between these two Caucasoid populations, suggests that concentration of the MBL-(MASP-2) complex, and therefore the function of activating complement, depends not only on the quantity of MBL in serum and its oligomeric state, but also on the quantity of MASP-2 in serum. It is likely that in individuals with high MBL concentration there is excess free MBL not occupied by MASPs, particularly not by MASP-2.

Publisher

SAGE Publications

Subject

Pharmacology,Immunology,Immunology and Allergy

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