Histological Study of Murine Fibrosarcoma Treated with Prostaglandin Inhibitors

Author:

Valdez J.C.1,Mercau G.T.2,Vitalone H.2,Perdigon G.1

Affiliation:

1. Sección de Inmunología, Instituto de Microbiología, Facultad de Bioquímica, Química y Farmacia, Universidad Nacional de Tucumán. Ayacucho 491. (4000). Tucumán

2. Cátedra de Histologia, Facultad de Medicina, Universidad Nacional de Tucumán, República Argentina

Abstract

In a previous work we reported that treatment with indomethacin, aspirin and piroxicam in inbred BALB/c mice bearing a transplantable fibrosarcoma induced by methylcholanthrene produced tumor regressions in 45, 32 and 30 per cent of the animals, respectively. In the remaining mice, in which there was no tumor regression, tumor volumes varied (small 0.05<0,5 cm3 medium 0,5<1,35 cm3 and large > 1,35 cm3). In this histological study we observed that the antitumoral effect of these nonsteroidal antiinflammatory drugs occurred together with a remarkable tumor encapsulation and a decrease in the physical characteristics of malignancy of the tumor cells. The tumor-associated macrophages, which can be detected only by the iron-dextran phagocytosis but not by that of colloidal carbon or trypan blue, were found in the peritumoral area in all cases under study. Their numbers and/or phagocytic capacity were slightly increased in both regressing and small tumors with respect to large, medium and control tumors. These findings suggest that the action of these prostaglandin synthesis inhibiting drugs would permit tumor encapsulation by an improvement in the macrophage-fibroblast relationship together with a decrease in the malignancy of the tumor cells.

Publisher

SAGE Publications

Subject

Pharmacology,Immunology,Immunology and Allergy

Reference25 articles.

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Eicosanoids and the immunology of cancer;Cancer and Metastasis Reviews;1994-12

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3