Affiliation:
1. University Department of Pediatrics, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy
2. Italian Medicines Agency (AIFA), Rome, Italy
3. National Centre for Epidemiology, Surveillance and Health Promotion of National Institutes of Health, Rome, Italy
4. Department of Physiology and Pharmacology, University of Rome “Sapienza”, Rome, Italy
Abstract
Congenital HCMV infection is the most frequent congenital infection, with an incidence of 0.2–2.5% among all live births. About 11% of infected newborns show symptoms at birth, including hepato-splenomegaly, thrombocytopenia, neurologic involvement, hearing impairment and visual deficit. Moreover, 5–25% of the asymptomatic congenital HCMV-infected neonates will develop sequelae over months or even years. The relevant social burden, the economic costs of pre-natal screening, post-natal diagnosis, follow-up and possible therapy, although still limited, are the major factors to be considered. Several types of vaccines have been explored in order to develop an effective and safe HCMV vaccine: live attenuated, subunit, vectored, peptide, DNA, and subviral ones, but none are available for use. This review illustrates the different vaccine types studied to date, focusing on the possible vaccination strategy to be implemented once the HCMV vaccine is available, in terms of target population.
Subject
Pharmacology,Immunology,Immunology and Allergy
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献