TLR2: A Crossroads between Infections and Autoimmunity?-Reference-Cited by-同舟云学术

TLR2: A Crossroads between Infections and Autoimmunity?

Published:2011-07 Issue:3 Volume:24 Page:549-556
ISSN:2058-7384
Container-title:International Journal of Immunopathology and Pharmacology
language:en
Short-container-title:Int J Immunopathol Pharmacol

Author:

Borrello S.¹,Nicolò C.¹,Delogu G.²,Pandolfi F.³,Ria F.¹

Affiliation:

1. Institutes of General Pathology, Università Cattolica del S. Cuore, Rome, Italy

2. Institutes of Microbiology and Università Cattolica del S. Cuore, Rome, Italy

3. Institutes of Internal Medicine, Università Cattolica del S. Cuore, Rome, Italy

Abstract

Environment has both pathogenic and protective roles in the determination of autoimmune disease development, possibly through infectious agents. TLR2 has the capability to recognize the widest range of PAMPs, and it is important for the recognition of mycobacteria and gram-positive bacteria. Here we review recent information showing that TLR2 ligands, its signaling machinery and the effects of its engagement on T cell polarization and differentiation, all play a decisive role in experimental models of autoimmunity. Thus, we propose that engagement of TLR2 is an important crossroads between encounter with bacteria and development of self-reactive diseases.

Publisher

SAGE Publications

Subject

Pharmacology,Immunology,Immunology and Allergy

Link

http://journals.sagepub.com/doi/pdf/10.1177/039463201102400301

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