Lipoprotein (a) as a predictor of diabetic retinopathy in patients with type 2 diabetes: A systematic review-Reference-Cited by-同舟云学术

Lipoprotein (a) as a predictor of diabetic retinopathy in patients with type 2 diabetes: A systematic review

Published:2023-11 Issue:6 Volume:20 Page:
ISSN:1479-1641
Container-title:Diabetes and Vascular Disease Research
language:en
Short-container-title:Diabetes and Vascular Disease Research

Author:

Gholami Chahkand Mohammad Sadra¹,Esmaeilpour Moallem Fatemeh²,Qezelgachi Abolfazl³,Seifouri Kiana⁴,Pesaran Afsharian Armin⁵,sheikhzadeh Farzad⁶,poursalehi Atefe⁷,Fani Sadrabadi Fateme Sadat⁸,Saghab Torbati Mehrnush⁹,Ramezanzade Mohaddese¹⁰,Alishiri Goharsharieh¹¹,Ansari Arina¹²^ORCID,Zare Dehabadi Emad⁴,Karimi Matloub Saeed¹³,Sheikh Zahra¹⁴,Deravi Niloofar⁴,Mehrtabar Saba¹⁵,Chichagi Fatemeh¹⁶,Faal Hamedanchi Neda¹⁷,Arzaghi Mohammadreza¹⁸,Asadi Mahla¹⁹,Alsadat Dadkhah Parisa³,Ansari Akram²⁰

Affiliation:

1. Student Research Committee, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran

2. Student Research Committee, Golestan University of Medical Sciences, Gorgan, Iran

3. Student Research Committee, Qazvin University of Medical Sciences, Qazvin, Iran

4. Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

5. Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran

6. Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

7. Student Research Committee, School of Paramedical, Shahid Beheshti University of Medical Sciences, Tehran, Iran

8. Student Research Committee, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

9. Islamic Azad University of Zahedan, Zahedan, Iran

10. School of Medicine, Guilan University of Medical Sciences, Rasht, Iran

11. Students Research Committee, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran

12. Student Research Committee, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran

13. Students Research Committee, Qom University of Medical Sciences, Qom, Iran

14. Student Research Committee, School of Medicine, Babol University of Medical Sciences, Babol, Iran

15. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran

16. Students’ Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran

17. Faculty of Medicine, Islamic Azad University, Tehran Medical Sciences Branch, Tehran, Iran

18. Shahid Beheshti University of Medical Sciences, Tehran, Iran

19. Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

20. Medical College, Shantou University, Shantou, China

Abstract

Background Lipoprotein a (LP(a)), an LDL-like lipoprotein, known as a risk factor for cardiovascular diseases, has a controversial association with diabetic retinopathy in patients with type 2 diabetes—the current systematic review aimed to critically assess the association between LP(a) and diabetic retinopathy. Methods A systematic review of relevant studies was conducted after a thorough search in PubMed, Scopus, and Google Scholar electronic databases. We used English observational, case-control, and prospective cohort studies published up to August 2022, including type 2 diabetic patients as the population, diabetic retinopathy as the outcome, and LP(a) as the intervention. Result 17 relevant studies, including 4688 patients with diabetes, were included in this systematic review. While in 13 studies, Lipoprotein(a) was recognized as a risk factor for diabetic retinopathy, only three studies reported no evidence of a relationship between the two. Also, another study showed a mixed outcome of the relationship between LP(a) and diabetic retinopathy. Conclusion High serum lipoprotein(a) in patients with type 2 diabetes is considered a risk factor for diabetic retinopathy. However, further large-scaled cohort studies are still required to validate this finding.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine,Endocrinology, Diabetes and Metabolism,Internal Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/14791641231197114

Reference44 articles.

1. WHO. Diabetes. Global population: WHO. Available from: https://www.who.int/news-room/fact-sheets/detail/diabetes 2021.

2. Lipoprotein(a) plasma levels are not associated with incident microvascular complications in type 2 diabetes mellitus

3. Diabetic Retinopathy

4. Novel insights into DNA methylation and its critical implications in diabetic vascular complications