Body mapping of human cutaneous microcirculatory perfusion using a real-time laser Doppler imager

Abstract

There are many pathologies and/or surgical situations where understanding how cutaneous capillary blood flow is behaving would be of clinical benefit. Laser Doppler imaging (LDI) has long been considered an ideal candidate for this yet was never widely adopted. The technology was deemed too slow, needing minutes to record one image. Here, we present the use of a new, real-time LDI, which is sensitive enough to resolve pulsatile blood flow in the microcirculation and can record images and videos instantaneously. We show that when comparing the ratios of absolute perfusion images from different regions of the body, remarkably reproducible data can be obtained when looking at a control population of male volunteers. In the future, we plan to add more control and diseased groups, effectively giving the clinician a non-invasive, safe and easy-to-use diagnostic for assessing the extent of microcirculatory disorders and high-risk surgical situations.