Vacuum-Assisted Needle-Free Capillary Blood Sampling

Author:

Hoffman Michael1ORCID,McKeage James1,Ruddy Bryan12ORCID,Nielsen Poul12,Taberner Andrew12

Affiliation:

1. Auckland Bioengineering Institute, The University of Auckland, Auckland, New Zealand

2. Department of Engineering Science, The University of Auckland, Auckland, New Zealand

Abstract

Background: Poor glycemic management persists among people practicing insulin therapy in relation to type 1 and 2 diabetes despite a clear relationship with negative health outcomes. Skin penetration by jet injection has recently been shown as a viable method for inducing blood release from fingertips. This study examines the use of vacuum to enhance the volume of blood released and quantifies any dilution of the collected blood. Methods: A single-blind crossover study involving 15 participants, each receiving four different interventions, was conducted wherein each participant served as their own control. Each participant experienced fingertip lancing and fingertip jet injection, both with and without applied vacuum. Participants were divided into three equal groups to explore different vacuum pressures. Results: This study found that glucose concentration in blood collected under vacuum following jet injection and lancing were equivalent. We found that applying a 40 kPa vacuum following jet injection produced a 35-fold increase in the collected volume. We determined the limited extent to which the injectate dilutes blood collected following jet injection. The mean dilution of blood collected by jet injection was 5.5%. We show that jet injection is as acceptable to patients as lancing, while being equally suited for conducting glucose measurements. Conclusions: Vacuum significantly enhances the volume of capillary blood released from the fingertip without any difference in pain. The blood collected by jet injection with vacuum is equivalent to that from lancing for glucose measurement purposes.

Funder

James Cook Research Fellowship, Royal Society of New Zealand

Auckland Bioengineering Institute, University of Auckland, New Zealand

Science for Technological Innovation National Science Challenge (SfTI) of New Zealand

Publisher

SAGE Publications

Subject

Biomedical Engineering,Bioengineering,Endocrinology, Diabetes and Metabolism,Internal Medicine

Reference17 articles.

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Lancet-free blood sampling and collection for the management of diabetes;2023 IEEE 19th International Conference on Body Sensor Networks (BSN);2023-10-09

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