Effects of Aerobic Exercise on Systemic Insulin Degludec Concentrations in People With Type 1 Diabetes

Author:

Herzig David1ORCID,Groessl Michael2,Álvarez-Martínez Mario13,Reverter-Branchat Gemma1,Nakas Christos T45,Kosinski Christophe1,Stettler Christoph1,Bally Lia1

Affiliation:

1. Department of Diabetes, Endocrinology, Nutritional Medicine and Metabolism, Inselspital, Bern University Hospital, University of Bern, Bern, Canton of Bern, Switzerland

2. Department of Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern, Bern, Canton of Bern, Switzerland

3. Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot-Watt University, Edinburgh, UK

4. Laboratory of Biometry, School of Agriculture, University of Thessaly, Nea Ionia-Volos, Magnesia, Thessalia Sterea Ellada, Greece

5. University Institute of Clinical Chemistry, Inselspital, Bern University Hospital, University of Bern, Bern, Canton of Bern, Switzerland

Abstract

Background: There is conflicting evidence on the effect of exercise on systemic insulin concentrations in adults with type 1 diabetes. Methods: This prospective single-arm study examined the effect of exercise on systemic insulin degludec (IDeg) concentrations. The study involved 15 male adults with type 1 diabetes (age 30.7 ± 8.0 years, HbA1c 6.9 ± 0.7%) on stable IDeg regimen. Blood samples were collected every 15 minutes at rest, during 60 minutes of cycling (66% VO2max) and until 90 minutes after exercise termination. IDeg concentrations were quantified using high-resolution mass-spectrometry and analyzed applying generalized estimation equations. Results: Compared to baseline, systemic IDeg increased during exercise over time ( P < .001), with the highest concentrations observed toward the end of the 60-minute exercise (17.9% and 17.6% above baseline after 45 minutes and 60 minutes, respectively). IDeg levels remained elevated until the end of the experiment (14% above baseline at 90 minutes after exercise termination, P < .001). Conclusions: A single bout of aerobic exercise increases systemic IDeg exposure in adults on a stable basal IDeg regimen. This finding may have important implications for future hypoglycemia mitigation strategies around physical exercise in IDeg-treated patients.

Funder

novo nordisk canada

Diabetes Center Bern

engineering and physical sciences research council

université de montréal

Publisher

SAGE Publications

Subject

Biomedical Engineering,Bioengineering,Endocrinology, Diabetes and Metabolism,Internal Medicine

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Exercise in adults with type 1 diabetes mellitus;Nature Reviews Endocrinology;2022-10-31

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