MRI ultrasound fusion biopsy in prostate cancer detection: Are randomized clinical trials reproducible in everyday clinical practice?

Author:

Cattarino Susanna1,Forte Valerio2,Salciccia Stefano1,Drudi Francesco Maria2,Cantisani Valerio2,Sciarra Alessandro1,Fasulo Andrea3,Ciccariello Mauro2

Affiliation:

1. Department of Urology, Sapienza University of Rome, Rome, Italy

2. Department of Radiological, Oncological and Anatomo-Pathological Sciences, Sapienza University of Rome, Rome, Italy

3. ISTAT (Statistics Institute of Rome), Rome, Italy

Abstract

Introduction: The aim of this study was to evaluate the performance of multiparametric magnetic resonance imaging (mpMRI)–ultrasound (US) fusion-targeted biopsies (TB) in men with primary and repeated biopsies comparing the cancer detection rate (CDR) of random biopsies (RB) + TB versus only TB. Methods: The present study is a real-life study on patients with primary and prior negative prostate biopsies with suspicious PCa. A total of 130 men with prostate-specific antigen (PSA) value >2.5 ng/dL and/or abnormal digital rectal examination (DRE) were included in the study and subjected to mpMRI. Patients with >2 previous biopsies and/or with ⩾3 suspected lesions on MRI and/or prostate imaging-reporting and data system (PIRADS) value ⩾4 (n:30 pts) were subjected only to TB on the areas indicated by mpMRI. All the other patients (n:70 pts) were subjected to standard random laterally directed 10-core plus TB on the areas indicated by mpMRI. Results: The overall CDR was 53% (53/100). In relation to PIRADS score, the overall CDR was 0, 40% (12/30), 56.83% (29/51), and 84% (11/13) for PIRADS 2, 3, 4, and 5, respectively. According to biopsy modality, CDR for RB + TB was 50% (35/70) and CDR for TB was 60% (18/30) with a p-value of 0.3632. Discussion: MRI–US fusion biopsy is associated with a high CDR of clinically significant PCa (csPCa). MRI–US fusion biopsy could be a reasonable approach in patients with previous negative biopsy and high PIRADS score on MRI, to ensure a high CDR of csPCa and to reduce the diagnosis of clinically insignificant tumors.

Publisher

SAGE Publications

Subject

General Medicine

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