Pazopanib Is a Potential Treatment for Coronavirus-Induced Lung Injuries

Author:

Luan Yi1,Yuan Qianying1,Wang Qijun1ORCID,Compton Susan2ORCID,Wu Dianqing1,Tang Wenwen1

Affiliation:

1. *Department of Pharmacology, Vascular Biology and Therapeutic Program, Yale School of Medicine, New Haven, CT; and

2. †Department of Comparative Medicine, School of Medicine, Yale University, New Haven, CT

Abstract

Abstract Severe acute respiratory syndrome coronavirus 2, responsible for the severe acute respiratory syndrome known as COVID-19, has rapidly spread in almost every country and devastated the global economy and health care system. Lung injury is an early disease manifestation believed to be a major contributor to short- and long-term pathological consequences of COVID-19, and thus drug discovery aiming to ameliorate lung injury could be a potential strategy to treat COVID-19 patients. By inducing a severe acute respiratory syndrome–like pulmonary disease model through infecting A/J mice with murine hepatitis virus strain 1 (MHV-1), we show that i.v. administration of pazopanib ameliorates acute lung injuries without affecting MHV-1 replication. Pazopanib reduces cell apoptosis in MHV-1–infected lungs. Furthermore, we also identified that pazopanib has to be given no later than 48 h after the virus infection without compromising the therapeutic effect. Our study provides a potential treatment for coronavirus-induced lung injuries and support for further evaluation of pazopanib in COVID-19 patients.

Funder

HHS | NIH | National Heart, Lung, and Blood Institute

Publisher

The American Association of Immunologists

Subject

Immunology,Immunology and Allergy

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