Author:
Lepault F,Coffman R L,Weissman I L
Abstract
Abstract
Using a short-term in vivo assay, we studied bone marrow cells capable of homing to the thymus of lethally irradiated recipients. In the bone marrow, these cells lack the T cell markers Thy-1 and Lyt. Soon after their homing into the thymus, however, the immigrants begin to express Thy-1 and Lyt antigens, but not TL antigen. Unexpectedly, Lyt antigens appear to be expressed before Thy-1. These thymus-homing bone marrow cells seem to be already separated from the B cell lineage. Most of the homing cells are engaged in the cell cycle.
Publisher
The American Association of Immunologists
Subject
Immunology,Immunology and Allergy
Cited by
2 articles.
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1. Ontogeny of T Cells;Clinics in Immunology and Allergy;1985-06
2. Prothymocytes as target cells of T cell leukemogenesis in the mouse;Survey of Immunologic Research;1985-03