Pan-Bcl-2 Inhibitor, GX15-070 (Obatoclax), Decreases Human T Regulatory Lymphocytes while Preserving Effector T Lymphocytes: A Rationale for Its Use in Combination Immunotherapy-Reference-Cited by-同舟云学术

Pan-Bcl-2 Inhibitor, GX15-070 (Obatoclax), Decreases Human T Regulatory Lymphocytes while Preserving Effector T Lymphocytes: A Rationale for Its Use in Combination Immunotherapy

Published:2014-02-10 Issue:6 Volume:192 Page:2622-2633
ISSN:0022-1767
Container-title:The Journal of Immunology
language:en
Short-container-title:J.I.

Author:

Kim Peter S.,Jochems Caroline,Grenga Italia,Donahue Renee N.,Tsang Kwong Y.,Gulley James L.,Schlom Jeffrey,Farsaci Benedetto

Publisher

The American Association of Immunologists

Subject

Immunology,Immunology and Allergy

Reference39 articles.

1. Mechanisms of Antileukemic Activity of the Novel Bcl-2 Homology Domain-3 Mimetic GX15-070 (Obatoclax)

2. Bcl-2 inhibitors induce apoptosis in chronic lymphocytic leukemia cells

3. Preclinical studies of the pan-Bcl inhibitor obatoclax (GX015-070) in multiple myeloma

4. Phase II Study of Obatoclax Mesylate (GX15-070), a Small-Molecule BCL-2 Family Antagonist, for Patients With Myelofibrosis

5. Phase I Dose Finding Studies of Obatoclax (GX15-070), a Small Molecule Pan-BCL-2 Family Antagonist, in Patients with Advanced Solid Tumors or Lymphoma

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