Affiliation:
1. Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Abstract
Abstract
A human T lymphoid cell line, PEER, dies by apoptosis in the presence of PMA and calcium ionophore. A new gene, TINUR, was cloned from apoptotic PEER cells. The expression of the TINUR gene is induced within 1 h after the cross-linking of the T cell Ag receptor complex. TINUR belongs to the NGFI-B/nur77 family of the steroid receptor superfamily and is an orphan receptor. TINUR binds to the same DNA sequence as NGFI-B/nur77. We also propose that the NGFI-B/nur77 family can be classified into two subtypes.
Publisher
The American Association of Immunologists
Subject
Immunology,Immunology and Allergy
Cited by
3 articles.
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