Human Class I Supertypes and CTL Repertoires Extend to Chimpanzees

Author:

Bertoni Roberto1,Sette Alessandro2,Sidney John2,Guidotti Luca G.1,Shapiro Max3,Purcell Robert4,Chisari Francis V.1

Affiliation:

1. *Scripps Research Institute, La Jolla, CA 92037;

2. †Epimmune Corporation, San Diego, CA 92037;

3. ‡Bioqual, Rockville, MD 20850; and

4. §National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892

Abstract

AbstractUsing an in vitro peptide stimulation strategy, two chimpanzees that were acutely infected by the hepatitis B virus (HBV) produced peripheral blood CTL responses to several HBV-encoded epitopes that are known to be recognized by class I-restricted CTL in acutely infected humans. One animal responded to three HBV peptides that, in humans, are restricted by HLA-A2; the other animal responded to three peptides that are restricted by HLA-B35 and HLA-B51, members of the HLA-B7 supertype in man. The peptides recognized by each chimp corresponded with the ability of its class I molecules to bind peptides containing the HLA-A2 and HLA-B7 supermotifs. Similar, apparently class I-restricted CTL responses to some of these peptides were also detected in occasional HBV-uninfected chimps. These results demonstrate that the CTL repertoire overlaps in humans and chimps and that the HLA-A2 and HLA-B7 supertypes extend to the chimpanzee. Based on these results, the immunogenicity and efficacy of vaccines designed to induce CTL responses to human HLA-restricted viral epitopes may be testable in chimpanzees.

Publisher

The American Association of Immunologists

Subject

Immunology,Immunology and Allergy

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