Integrating T Cell Activation Signals to Regulate Gene Expression through Cyclosporin-Sensitive NFAT

Author:

Kaye Jonathan1ORCID

Affiliation:

1. Research Division of Immunology, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA

Abstract

This Pillars of Immunology article is a commentary on three pivotal articles: “Nuclear factor of activated T cells contains Fos and Jun,” an article written by J. Jain, P. G. McCaffrey, V. E. Valge-Archer, and A. Rao, and published in Nature, in 1992, https://www.nature.com/articles/356801a0; “The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun,” written by J. Jain, P. G. McCaffrey, Z. Miner, T. K. Kerppola, J. N. Lambert, G. L. Verdine, T. Curran, and A. Rao, and published in Nature, in 1993, https://www.nature.com/articles/365352a0; and “Isolation of the cyclosporin-sensitive T cell transcription factor NFATp,” written by P. G. McCaffrey, C. Luo, T. K. Kerppola, J. Jain, T. M. Badalian, A. M. Ho, E. Burgeon, W. S. Lane, J. N. Lambert, T. Curran, et al., and published in Science, in 1993, https://www.science.org/doi/10.1126/science.8235597.

Publisher

The American Association of Immunologists

Subject

Immunology,Immunology and Allergy

Reference17 articles.

1. Effects of the new anti-lymphocytic peptide cyclosporin A in animals;Borel;Immunology,1977

2. The mechanism of action of cyclosporin A and FK506;Schreiber;Immunol. Today,1992

3. FK-506, a novel immunosuppressant isolated from a Streptomyces. II. Immunosuppressive effect of FK-506 in vitro;Kino;J. Antibiot. (Tokyo),1987

4. Effects of cyclosporin A on the metabolism of unstimulated and mitogen-activated lymphocytes;Kay;Immunology,1983

5. The immunosuppressant FK506 selectively inhibits expression of early T cell activation genes;Tocci;J. Immunol.,1989

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