Cutting Edge: Targeted Ligation of CTLA-4 In Vivo by Membrane-Bound Anti-CTLA-4 Antibody Prevents Rejection of Allogeneic Cells
Author:
Publisher
The American Association of Immunologists
Subject
Immunology,Immunology and Allergy
Reference24 articles.
1. CTLA-4 can function as a negative regulator of T cell activation
2. CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation.
3. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
4. Lymphoproliferative Disorders with Early Lethality in Mice Deficient in Ctla-4
5. Lymphoproliferation in CTLA-4–Deficient Mice Is Mediated by Costimulation-Dependent Activation of CD4 + T Cells
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