Costimulatory Molecule Immune Enhancement in a Plasmid Vaccine Model Is Regulated in Part Through the Ig Constant-Like Domain of CD80/86-Reference-Cited by-同舟云学术

Costimulatory Molecule Immune Enhancement in a Plasmid Vaccine Model Is Regulated in Part Through the Ig Constant-Like Domain of CD80/86

Published:2003-10-06 Issue:8 Volume:171 Page:4311-4319
ISSN:0022-1767
Container-title:The Journal of Immunology
language:en
Short-container-title:J Immunol

Author:

Agadjanyan Michael G.,Chattergoon Michael A.,Holterman Mark J.,Monzavi-Karbassi Behjatolah,Kim J. Joseph,Dentchev Tzvete,Wilson Darren,Ayyavoo Velpandi,Montaner Luis J.,Kieber-Emmons Thomas,Sekaly Rafick-P.,Weiner David B.

Publisher

The American Association of Immunologists

Subject

Immunology,Immunology and Allergy

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1. Absence of B7-dependent responses in CD28-deficient mice

2. Peptide mimics of the CTLA4-binding domain stimulate T-cell proliferation

3. CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation.

4. CTLA-4 ligation blocks CD28-dependent T cell activation.

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